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Research
Electrophysiology Research
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Electrophysiology Basic Research

Mission Statement

Under the direction of Dr. Jie Cheng, the research goals of the Electrophysiology (EP) Research Lab are: (1) to elucidate the pathophysiological mechanisms of various arrhythmias; (2) to develop new lines of inquiry in arrhythmia research using novel technology such as optical mapping systems; and (3) to develop new therapeutic strategies to treat various arrhythmias.

Projects

  • Non-cholinergic vagal effects on atrial electrophysiological properties and vulnerability to atrial fibrillation
  • Role of cytoskeletal proteins in arrhythmias
  • Use of stem cell therapy to restore electrical activity in hibernating heart
  • Proarrhythmic effects of B-type natriuretic peptide on failing heart
  • Genetic screening in LQTS and Brugada Syndrome

The following achievements represent the current research in the EP Basic Research Laboratory:  

  • Defined that the action of a novel peptide (small protein), vasoactive intestine polypeptide (VIP), is vagally mediated and leads to the development of atrial fibrillation in animal models.
  • Demonstrated the proarrhythmic effects of a peptide, brain natriuretic peptide (BNP), which can be detected in the blood of a patient population and confirmed the effects of BNP in an animal model.

Department Staff

  • Jie Cheng, MD, PhD, FACC – Director 
  • Yutao Xi, MD, PhD – Research Associate
  • Junping Sun, MD, PhD – Research Fellow
  • Shahrzad Abbasi, MS – Senior Research Assistant

Links

Heart Rhythm Society
www.hrsonline.org

Research Support 

Agency: American Heart Association Grant-in-Aid

Principal Investigator: Jie Cheng, MD, PhD

Title: Mechanisms underlying vasoactive intestine polypeptide's effects on atrial vulnerability to fibrillation

Contact Information and Location

Electrophysiology Basic Research Laboratory 
Jie Cheng, MD, PhD
E-mail: jcheng@heart.thi.tmc.edu
Phone: 832-355-2573

Mailing address:
MC 2-255 
PO Box 20345
Houston, TX 77225-0345

The Texas Heart Institute at St. Luke's Hospital - The Denton A. Cooley BuildingTexas Heart Institute — the Denton A. Cooley Building is located at 6770 Bertner Avenue. The Institute is adjacent to St. Luke's Hospital in the Texas Medical Center (TMC), near the intersection of Fannin Street and Holcombe Boulevard.

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